Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GPR37 / neuroprotectin signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| GPR37 | participates_in | gene | 0.42 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution | 0.447 | neurodegeneration | Neuroinflammation resolution mechanisms |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.552
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Role and regulatory mechanism of GPR37 in neurological diseases. [PMID:40822851] | Liu S, Bai T, Liu X, Zhao W, Li X, Sui Y | Front Cell Neurosci | 2025 | 1 |
| Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's di [PMID:39913287] | Ma Q, Tian JL, Lou Y, Guo R, Ma XR, Wu J | Cell Rep | 2025 | 1 |
| Inflammation and Infection in Pain and the Role of GPR37. [PMID:36430912] | Zhang Q, Bang S, Chandra S, Ji RR | Int J Mol Sci | 2022 | 1 |
| Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 [PMID:34678058] | Qian Z, Li H, Yang H, Yang Q, Lu Z, Wang | Sci Adv | 2021 | 1 |
| GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. [PMID:30010619] | Bang S, Xie YK, Zhang ZJ, Wang Z, Xu ZZ, | J Clin Invest | 2018 | 1 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| GPR37 processing in neurodegeneration: a potential marker for Parkinson's Diseas [PMID:39256360] | ["Argerich J", "Garma L", "L\u00f3pez-Ca | NPJ Parkinson's disease | 2024 | 0 |
| Activation of GPR37 in macrophages confers protection against infection-induced [PMID:33731716] | Bang S, Donnelly CR, Luo X, Toro-Moreno | Nature communications | 2021 | 0 |
| Disparities in maternal health services in sub-Saharan Africa. [PMID:29572718] | ["Woldegiorgis M", "Hiller J", "Mekonnen | International journal of publi | 2018 | 0 |
| Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycopr [PMID:28642167] | ["Smith B", "Giddens M", "Neil J", "Owin | Neuroscience | 2017 | 0 |
| Research Designs for Intervention Research with Small Samples II: Stepped Wedge [PMID:26017633] | ["Fok C", "Henry D", "Allen J"] | Prevention science : the offic | 2015 | 0 |
| Global genomic profiling reveals an extensive p53-regulated autophagy program co [PMID:23651856] | ["Kenzelmann Broz D", "Spano Mello S", " | Genes & development | 2013 | 0 |
| Phylogenetic-based propagation of functional annotations within the Gene Ontolog [PMID:21873635] | ["Gaudet P", "Livstone M", "Lewis S", "T | Briefings in bioinformatics | 2011 | 0 |
| Pael receptor induces death of dopaminergic neurons in the substantia nigra via [PMID:17116640] | ["Kitao Y", "Imai Y", "Ozawa K", "Kataok | Human molecular genetics | 2007 | 0 |
| Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and [PMID:16539653] | ["Kubota K", "Niinuma Y", "Kaneko M", "O | Journal of neurochemistry | 2006 | 0 |
| Pael receptor, endoplasmic reticulum stress, and Parkinson's disease. [PMID:14579121] | Takahashi R, Imai Y | Journal of neurology | 2003 | 0 |
| Neurodegeneration: how does parkin prevent Parkinson's disease? [PMID:12842030] | Cookson MR | Current biology : CB | 2003 | 0 |